Mohammad Zakerin Abedin1*, Md. Easin Arfat2, Samim Mia1, Jayanta Das1, Farjana Akter Koly2, Md. Rezaul Karim2, Noor-E-Kashif Farnaz2, Mst. Nadia Afrin3, Rubait Hasan4, Jamiatul Husna Shathi4, Afroza Sultana5, and Abdullah Akhtar Ahmed1
1Dept. of Microbiology, Khwaja Yunus Ali University, Sirajganj, Bangladesh; 2Dept. of Microbiology, University of Chittagong, Chittagong, Bangladesh; 3Daffodil Hospital, Enayetpur, Sirajganj, Bangladesh; 4Dept. of Biochemistry and Biotechnology, Khwaja Yunus Ali University, Sirajganj, Bangladesh; and 5Dept. of Pharmacy, Khwaja Yunus Ali University, Sirajganj, Bangladesh.
*Correspondence: zakerin.abedin@kyau.edu.bd (Mohammad Zakerin Abedin, Assistant Professor & Head, Dept. of Microbiology, School of Biomedical Sciences, Khwaja Yunus Ali University, Sirajganj, Bangladesh).
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ABSTRACT
Urinary tract infections (UTIs) are broadly common in inpatient and outpatient males and females of different ages and comprise 40% of the nosocomial infections that collectively cause 150 million deaths per year. The right care is obligatory if the patients do not want to die, but this is hard to do because the things that make people sick are getting better at resisting antibiotics (AMR). Collected specimens were examined microscopically and cultured on Cystine Lactose Electrolyte Deficient (CLED) agar to isolate the pathogens. Isolated pathogens were identified through colony morphology, microscopic studies, and biochemical indications. Lastly, antimicrobial responsiveness patterns of the pathogens were determined by the disc diffusion method to find possible antibiotics that could treat the disease well. Among 17.67% of positive cultures, 73.58% were females, and 26.42% were males, dominated by the age group ≥37 years (49.06%). E. coli (56.6%), Enterococcus faecalis (26.4%), Pseudomonas aeruginosa (7.5%), Staphylococcus aureus (3.8%), Acinetobacter baumannii (3.8%). Moreover, Serratia marcescens (1.9%) were the isolated pathogens, with 69.8% Gram-negative and 30.2% Gram-positive. The most effective antibiotics were amikacin (88.68%), levofloxacin (88.68%), ciprofloxacin (86.79%), gentamicin (84.91%), and imipenem (84.91%). The least effective antibiotics were mecillinam (50.94%), cefuroxime (37.74%), ceftazidime (37.74%), meropenem (35.85%), and cefotaxime (33.96%). To treat and suggest antimicrobials, routine and emphatic research about urogenital pathogens and their antibiotic susceptibilities is required. Patients should be prescribed appropriate antimicrobial therapies after completing a standard test of pathogen identification and antibiotic resistance pattern determination. This study would be of extensive importance to patients and physicians in picking appropriate antimicrobial therapies for empiric treatment.
Keywords: Urinary tract infections (UTIs), CLED, Uropathogens, and Antibiotic susceptibility patterns.
Citation: Abedin MZ, Arfat ME, Mia S, Das J, Koly FA, Karim MR, Farnaz NEK, Afrin MN, Hasan R, Shathi JH, Sultana A, and Ahmed AA. (2022). Symptomatic pathogen frequency and antibiogram patterns of bacterial isolates in urinary tract infections, Sirajganj Sadar, Bangladesh. Eur. J. Med. Health Sci., 4(4), 111-121. https://doi.org/10.34104/ejmhs.022.01110121
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