Md. Ahasun Habib1, 2*, Sonia Akter3, Arrafy Rahman4, Jyoti Sikder2, Fahmida Khatun2, Md. Furkanur Rahaman Mizan5, Md. Ashrafudoulla5 and Muhammad Abdul Hannan2
1Dept. of Food Science and Technology, International Institute of Applied Science and Technology, Rangpur, Bangladesh; 2Dept. of Biotechnology, Bangladesh Agricultural University, Mymensingh, Bangladesh; 3Pharmacy Discipline, Khulna University, Khulna, Bangladesh; 4Dept. of Microbiology, International Institute of Applied Science and Technology, Rangpur, Bangladesh; and 5Dept. of Food Science and Technology, Chung-Ang University, Gyunggido, South Korea.
*Correspondence: habibku1107@gmail.com
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ABSTRACT
Now-a-days, the use of natural products has increased its popularity day by day all over the world. One of the most effective therapeutic medicinal plants is Bacopa monnieri. In the current study, the methanolic distillate of B. monnieri was designed for an antidepressant in mice models. B. monnieri was evaluated for anti-depressant venture in the forced swimming test (FST), tail suspension test (TST), and elevated plus maze test. In the force swimming test, imipramine (30 mg/kg) used as a standard drug and in TST as well as elevated plus maze test, diazepam (10 mg/kg) used as a standard and the plant extract (100 mg/kg and 200 mg/kg) was administered as test group and the control group was given deionized water. In this test, the test extracts (100 mg/kg and 200 mg/kg) compare to both the control and standard group. The higher dose (200 mg/kg) represented a more significant effect than a dose of 100 mg/kg. In comparison to the standard and control, at dose 200 mg/kg represented a more significant effect at p<0.05 among three of the test.
Keywords: Bacopa monnieri, Neuropharmacological Activities, Methanolic Extract, TST, and Mice Model.
Citation: Habib MA, Akter S, Rahman A, Sikder J, Khatun F, Mizan MFR, Ashrafudoulla M, and Hannan MA. (2019). Evaluation of neuropharmacological activities of methanolic extract of Bacopa monnieri L. in mice model. Eur. J. Med. Health Sci., 1(6), 41-49. https://doi.org/10.34104/ejmhs.01941049
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